The eldest of ten children born to Angelo and Maria Romano Clerici; hers was a poor but pious family with two of her brothers becoming monks, one sister a Sister of the Precious Blood.
Received a Master’s degree from the College of the Sisters of the Precious Blood in Monza, Italy. Taught in Lainate, Italy from 1880 to 1883. During her time in college and her work as a teacher, Alfonsa had felt a call to religious life, but her work helped support her family, and she stayed with it. She finally answered the call, and on August 15, 1883 joined the Sisters of the Most Precious Blood in Monza. Teacher at the College in Monza. Director of the College on November 22, 1898.
She was beatified on October 3, 2010 by Pope Benedict XVI. Beatification recognition celebrated in the Piazza of San Eusebio, Diocese of Vercelli, Italy with Archbishop Angelo Amato as chief celebrantthe beatification miracle involved the healing of a nearly-fatal heart condition of Mr Nedo Frosini following the prayers of his wife, Carla Demi Frosini, for the intervention of Blessed Alfonsa.